Immunoprotection of Mice against Schistosomiasis Mansoni Using Solubilized Membrane Antigens
نویسندگان
چکیده
منابع مشابه
Immunoprotection of Mice against Schistosomiasis Mansoni Using Solubilized Membrane Antigens
BACKGROUND Schistosomiasis continues to be one of the most prevalent parasitic diseases in the world. Despite the existence of a highly effective antischistosome drug, the disease is spreading into new areas, and national control programs do not arrive to complete their tasks particularly in low endemic areas. The availability of a vaccine could represent an additional component to chemotherapy...
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We have constructed vectors that permit the expression in Escherichia coli of Schistosoma mansoni fatty acid-binding protein 14 (Sm14) in fusion with the nontoxic, but highly immunogenic, tetanus toxin fragment C (TTFC). The recombinant six-His-tagged proteins were purified by nickel affinity chromatography and used in immunization and challenge assays. Animals inoculated with TTFC in fusion wi...
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Increased number of mast cells at the site of infection is widely regarded as important host defense against parasites. The kinetics of mucosal mast cells and connective tissue mast cells responses were studied in the intestines of 68 female CFLP mice infected with 100 Schistosoma mansoni cercariae. The number of mucosal mast cells and the connective tissue mast cells increased from week 3 and ...
متن کاملSchistosoma mansoni cercaria and schistosomulum antigens in serodiagnosis of schistosomiasis.
Schistosoma mansoni cercaria and schistosomulum obtained in vitro were used in immunofluorescence (IF) tests and indirect hemagglutination (IHA) tests of 137 study sera, 44 from subjects infected with S. mansoni and 93 from healthy subjects residing outside areas endemic for the disease. The results of these tests were compared with those obtained by testing the same sera using conventional adu...
متن کاملmast cells kinetics during experimental schistosomiasis mansoni in mice
increased number of mast cells at the site of infection is widely regarded as important host defense against parasites. the kinetics of mucosal mast cells and connective tissue mast cells responses were studied in the intestines of 68 female cflp mice infected with 100 schistosoma mansoni cercariae. the number of mucosal mast cells and the connective tissue mast cells increased from week 3 and ...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2013
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0002254